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. 1979 Oct 15;184(1):181-4.
doi: 10.1042/bj1840181.

Structure--activity relationship of inhibitors of hydroxyapatite formation

G Williams, J D Sallis

Structure--activity relationship of inhibitors of hydroxyapatite formation

G Williams et al. Biochem J. .

Abstract

The relative abilities of some compounds to inhibit the transformation of amorphous calcium phosphate into hydroxyapatite were determined. Organic diphosphates, fructose 1,6-bisphosphate, pyrophosphate, imidodiphosphate and 3-phospholycerate all inhibited to various degrees. Strong inhibition was observed with phosphonoformate, and phosphocitrate proved to be the most powerful of the inhibitors examined. On the basis of these new findings an improved concept of the structure--activity relationship of inhibitors is proposed and mechanisms for inhibitor action are discussed.

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References

    1. Calcif Tissue Res. 1976 Dec 22;22(2):149-57 - PubMed
    1. Horiz Biochem Biophys. 1977;4:1-30 - PubMed
    1. Kidney Int. 1978 May;13(5):344-60 - PubMed
    1. J Dent Res. 1972 Mar-Apr;51(2):324-32 - PubMed
    1. Arch Biochem Biophys. 1970 Oct;140(2):318-25 - PubMed

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