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. 1969 Sep 27;3(5673):757-8.
doi: 10.1136/bmj.3.5673.757.

Virulence of temperature-sensitive mutants of influenza virus

J S Mackenzie

Virulence of temperature-sensitive mutants of influenza virus

J S Mackenzie. Br Med J. .

Abstract

The acquisition of temperature-mutant (ts) defects in a strain of influenza virus has been shown in mice to be associated with diminished virulence, though the antibody-producing stimulus remained. It is suggested that three advantages may make ts strains potential sources of attenuated live influenza vaccine-the ease of obtaining the strains, the ease of testing the vaccine strain, and the high yield of vaccine doses from a single egg.

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References

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    1. J Virol. 1968 Aug;2(8):778-86 - PubMed
    1. C R Hebd Seances Acad Sci. 1961 Nov 6;253:2164-6 - PubMed

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