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. 1969 Nov;37(3):680-8.
doi: 10.1111/j.1476-5381.1969.tb08506.x.

Sodium-dependent accumulation of 5-hydroxytryptamine by rat blood platelets

J M Sneddon

Sodium-dependent accumulation of 5-hydroxytryptamine by rat blood platelets

J M Sneddon. Br J Pharmacol. 1969 Nov.

Abstract

1. The influence of sodium and potassium on the accumulation of 5-hydroxytryptamine (5-HT) by rat blood platelets was investigated.2. An absolute dependence of 5-HT uptake on the sodium concentration in the medium was found.3. Removal of potassium reduced the uptake by about 60%. High concentrations of potassium inhibited sodium-dependent accumulation.4. The observations have been discussed in terms of a carrier-mediated transport process for 5-HT operating in the platelet membrane.

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References

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