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. 1969 Oct;115(1):109-11.
doi: 10.1042/bj1150109.

An accuate method for measurement of aldosterone production

J P Thomas, R J Oake

An accuate method for measurement of aldosterone production

J P Thomas et al. Biochem J. 1969 Oct.

Abstract

A method is described for isolation of the acid-hydrolysable metabolite of aldosterone in sufficient purity to measure accurately the daily production rate. Values obtained with six hospital patients were 84-131mug./day on a daily intake of 100m-equiv. of Na(+) and 227-464mug./day on a daily intake of 10m-equiv. of Na(+). Corresponding values for aldosterone excretion were also recorded, but these are a poor index of production rate since they represent from 1.6 to 9.8% of the total daily output of aldosterone.

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