doi: 10.1126/science.166.3910.1274.
Corticosterone regulation of tryptophan hydroxylase in midbrain of the rat
- PMID: 5350319
- DOI: 10.1126/science.166.3910.1274
Item in Clipboard
Corticosterone regulation of tryptophan hydroxylase in midbrain of the rat
Science.
.
Abstract
The tryptophan hydroxylase activity in the rat midbrain decreases after adrenalectomy and is restored by treatment with corticosterone. Cycloheximide, adminiistered intracisternally, prevents the restoration of the enzyme activity by corticosterone. Cycloheximide administration to adrenalectomized rats resutlts in a further decrease in the enzyme activity. an indication that the enzyme has a rapid turnover even in the absence of corticosterone.
Similar articles
-
Glucocorticoids as a regulatory factor for brain tryptophan hydroxylase during development.Dev Neurosci. 1980;3(4-6):217-23. doi: 10.1159/000112394. Dev Neurosci. 1980. PMID: 7460794
-
Adrenalcortical influence on rat brain tryptophan hydroxylase activity.Brain Res. 1974 Sep 27;78(2):291-302. doi: 10.1016/0006-8993(74)90553-8. Brain Res. 1974. PMID: 4277348 No abstract available.
-
Lack of effect of various endocrine manipulations on tryptophan hydroxylase activity of individual nuclei of the hypothalamus, limbic system, and midbrain of the rat.Endocrinology. 1976 Mar;98(3):743-7. doi: 10.1210/endo-98-3-743. Endocrinology. 1976. PMID: 1261494
-
Early response of rat brain tryptophan hydroxylase activity to cycloheximide, puromycin and corticosterone.J Neurochem. 1976 Sep;27(3):773-8. doi: 10.1111/j.1471-4159.1976.tb10407.x. J Neurochem. 1976. PMID: 61255 No abstract available.
-
Tryptophan hydroxylase of the central nervous system: effect of intraventricular 5,6- and 5,7-dihydroxytryptamine.Adv Biochem Psychopharmacol. 1974;10:93-101. Adv Biochem Psychopharmacol. 1974. PMID: 4603031 Review. No abstract available.
Cited by
-
Enzyme activity changes relevant to the control of tryptophan metabolism.Biochem J. 1972 Nov;130(2):50P-51P. doi: 10.1042/bj1300050p. Biochem J. 1972. PMID: 4664577 Free PMC article. No abstract available.
-
Adrenocorticoids control 5-hydroxytryptamine metabolism in rat brain.J Neural Transm. 1978;42(1):63-71. doi: 10.1007/BF01262730. J Neural Transm. 1978. PMID: 641544
-
Synergistic effects of dehydroepiandrosterone and fluoxetine on proliferation of progenitor cells in the dentate gyrus of the adult male rat.Neuroscience. 2009 Feb 18;158(4):1644-51. doi: 10.1016/j.neuroscience.2008.10.035. Epub 2008 Oct 30. Neuroscience. 2009. PMID: 19068226 Free PMC article.
-
Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice.Mol Psychiatry. 2008 May;13(5):498-506. doi: 10.1038/sj.mp.4002041. Epub 2007 Jul 10. Mol Psychiatry. 2008. PMID: 17622221 Free PMC article.
-
Chronic citalopram administration causes a sustained suppression of serotonin synthesis in the mouse forebrain.PLoS One. 2009 Aug 27;4(8):e6797. doi: 10.1371/journal.pone.0006797. PLoS One. 2009. PMID: 19710918 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
