doi: 10.1126/science.166.3910.1280.
Plus and minus single-stranded DNA separately encapsidated in adeno-associated satellite virions
- PMID: 5350322
- DOI: 10.1126/science.166.3910.1280
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Plus and minus single-stranded DNA separately encapsidated in adeno-associated satellite virions
Science.
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Abstract
Based on physical and chemical determinations, the mnolecular weight of the type 4 adeno-satellite virus is 5.4 X 10(6) daltons, and the virion contains 1.4 X 10(6) daltons of DNA. Denaturation and renaturation studies indicate that the viral genome is a single-stranded DNA molecule and that each virion contains either a minus or a plus strand. Upon extraction, the minus and plus strands unite to form double-stranded DNA molecules with no obvious excess of unpaired strands.
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