Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979;52(3):337-41.
doi: 10.1007/BF00278682.

Calculating genetic risk figures using a programmable pocket calculator

G R Stalder

Calculating genetic risk figures using a programmable pocket calculator

G R Stalder. Hum Genet. 1979.

Abstract

In autosomal irregular dominant as well as in sex-linked recessive inheritance, heterozygosity probabilities for up to six or eight pedigree members with unknown genotype can easily be calculated using a programmable pocket calculator. The application of the underlying combinatorial programs is explained by means of two relevant examples. Genetic counsellors without a computer at hand are provided with a simple and accurate method for calculating genetic risk figures taking into account pedigree data, incidence and/or mutation rate, reproductive fitness, as well as penetrance or results of heterozygosity tests of the disease in question.

PubMed Disclaimer

References

    1. Clin Genet. 1975 May-Jun;7(5):361-7 - PubMed
    1. J Pediatr. 1968 Jan;72(1):121-30 - PubMed
    1. Clin Genet. 1972;3(6):501-4 - PubMed