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. 1969 Oct;5(4):439-42.

Liver damage and isoniazid allergy

E S Assem, N Ndoping, H Nicholson, J R Wade

Liver damage and isoniazid allergy

E S Assem et al. Clin Exp Immunol. 1969 Oct.

Abstract

A patient with pulmonary tuberculosis developed jaundice and manifestations of generalized allergic reaction while receiving combined treatment with streptomycin, p-aminosalicylate and isonicotinic acid hydrazide. Amongst various tests for allergy, the lymphocyte transformation test provided evidence of allergy to isonicotinic acid hydrazide. Follow-up suggested successful `desensitization', and plasma glutamic oxaloacetic transaminase showed only a temporary tendency to rise whilst desensitization was being carried out.

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References

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