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. 1969 Dec;100(3):1371-7.
doi: 10.1128/jb.100.3.1371-1377.1969.

Pyrimidine synthesis in Neurospora crassa: gene-enzyme relationships

D F Caroline

Pyrimidine synthesis in Neurospora crassa: gene-enzyme relationships

D F Caroline. J Bacteriol. 1969 Dec.

Abstract

A new series of pyrimidine-requiring mutants of Neurospora has been isolated and all enzymes involved in pyrimidine biosynthesis are represented by at least one mutant. Among these mutants is included a single isolate for a new locus, pyr-6. This mutant is deficient in dihydroorotase (DHOase) and represents the only enzymatic step in orotate synthesis for which no mutant previously had been found. This mutant, which mapped genetically on the right arm of linkage group V, is unlinked to any of the other pyrimidine mutants. The DHOase-deficient mutant is also characterized by an unexpected growth behavior. The pyr-1 locus has been specifically associated with a lack of dihydroorotate dehydrogenase (DHOdehase). Mutants isolated in this series for other pyrimidine loci have been related to previously isolated mutants by allelism, recombination, and accumulation studies.

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References

    1. Proc Natl Acad Sci U S A. 1954 Mar;40(3):192-200 - PubMed
    1. J Clin Invest. 1959 May;38(5):798-809 - PubMed
    1. Proc Natl Acad Sci U S A. 1965 Jun;53(6):1483-9 - PubMed
    1. J Bacteriol. 1968 Mar;95(3):824-32 - PubMed
    1. Proc Natl Acad Sci U S A. 1951 Jul;37(7):396-9 - PubMed

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