Quantitative studies on the tissue localization of influenza virus in ferrets after intranasal and intravenous or intracardial inoculation

Abstract

A quantitative survey of relevant organs showed that in ferrets, influenza virus localized and grew significantly only in nasal mucosa after inoculation directly into the blood stream and predominantly in that site after intranasal inoculation. In the latter case, lung and trachea became infected but to a lesser extent than nasal mucosa.