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. 1969 Jul;113(4):721-5.
doi: 10.1042/bj1130721.

Acetylation of serotonin in vitro by a human N-acetyltransferase

T A White, J W Jenne, D A Evans

Acetylation of serotonin in vitro by a human N-acetyltransferase

T A White et al. Biochem J. 1969 Jul.

Abstract

1. There is a well-recognized genetic polymorphism for the N-acetylation of isoniazid and sulphamethazine by human livers. 2. Serotonin was found to be acetylated by human liver enzyme preparations and the N-acetylserotonin formed was identified and determined quantitatively. 3. In 13 livers examined there was a wide variability in the capacity to acetylate serotonin that did not correlate with the capacity of the same livers to acetylate isoniazid and sulphamethazine. The results suggest that serotonin is not a natural substrate for the polymorphic N-acetyltransferase and that it may be acetylated by a different enzyme.

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References

    1. J Clin Invest. 1965 Dec;44(12):1992-2002 - PubMed
    1. Biochem Pharmacol. 1967 Sep 9;16(9):1793-9 - PubMed
    1. Biochem Pharmacol. 1968 Aug;17(8):1543-52 - PubMed
    1. Ann N Y Acad Sci. 1968 Jul 31;151(2):742-52 - PubMed
    1. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed