Cell mediated lympholysis in man. Patterns of killing power in relation to the HL-A system

Abstract

In general it can be said that the HL-A (LA and FOUR) antigens seem to be of major qualitative and partly quantitative importance for the degree of destruction in Cell Mediated Lympholysis (CML). This has been established by analyses of 1299 effector/target combinations involving 97 different healthy individuals. The main observation is that the cytolytic capacity of MLC effectors is positively ranked with the number of HL-A (LA and FOUR) antigens introduced by the incompatibility between stimulator, effector and target lymphocytes. However, the fact that not all cytolytic situations can be explained by the HL-A system stresses that other specific antigens (Target Determinants) may interfere with the Cell Mediated Lympholysis.