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. 1979 Dec;38(6):553-7.
doi: 10.1136/ard.38.6.553.

Liposome-incorporated corticosteroids. II. Therapeutic activity in experimental arthritis

N C Phillips, D P Thomas, C G Knight, J T Dingle

Liposome-incorporated corticosteroids. II. Therapeutic activity in experimental arthritis

N C Phillips et al. Ann Rheum Dis. 1979 Dec.

Abstract

The anti-inflammatory activity of liposomes containing cortisol palmitate was determined in experimental acute arthritis in the rabbit knee by measuring joint temperature and diameter. The therapeutic activity of the liposome preparation was dose-dependent for both these parameters of inflammation. Liposomal corticosteroid therapy was effective also in decreasing the joint temperature of an acute inflammatory 'flare' superimposed on an underlying chronic arthritis. Phosphatidic acid was necessary for expression of full anti-inflammatory activity of the liposome preparation.

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