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. 1970 Jan 1;131(1):207-21.
doi: 10.1084/jem.131.1.207.

Induction of rabbit antibody with molecular uniformity after immunization with group C streptococci

K Eichmann, H Lackland, L Hood, R M Krause

Induction of rabbit antibody with molecular uniformity after immunization with group C streptococci

K Eichmann et al. J Exp Med. .

Abstract

Antibodies with uniform properties may occur in rabbits after immunization with Group C streptococci. These precipitating antibodies possess specificity for the group-specific carbohydrate. Not uncommonly, their concentration is between 20 and 40 mg/ml of antiserum. Evidence for molecular uniformity in the case of one of these antibodies, described in detail here, includes: individual antigenic specificity; monodisperse distribution of the light chains by alkaline urea polyacrylamide disc electrophoresis; and a single amino acid in each of the first three N-terminal positions of the light chains. When the amino acid sequence of rabbit antibody b+ light chains (kappa type) are aligned against their human kappa counterparts, a definite homology is observed between the N-terminus of the human and the rabbit variable region.

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References

    1. Biochem Biophys Res Commun. 1964;14:399-403 - PubMed
    1. Arch Biochem Biophys. 1962 Sep;Suppl 1:174-80 - PubMed
    1. J Immunol. 1967 Apr;98(4):710-5 - PubMed
    1. Science. 1966 May 27;152(3726):1253-5 - PubMed
    1. Science. 1963 Jun 14;140(3572):1218-9 - PubMed