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. 1970 Feb 6;167(3919):896-8.
doi: 10.1126/science.167.3919.896.

Dentin matrix transformation: rapid induction of alkaline phosphatase and cartilage

C B Huggins, M R Urist

Dentin matrix transformation: rapid induction of alkaline phosphatase and cartilage

C B Huggins et al. Science. .

Abstract

An acid-insoluble fraction of rat dentin rapidly initiates a chain reaction in mesenchyma after allogeneic transplantation to the subcutaneous tissues. The tooth matrix induced alkaline phosphatase activity within 24 hours; cartilage appeared within 5 days; bone and bone marrow formed within 14 days. The induced cartilage disappeared within 5 weeks, but bone persisted at least 1 year.

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