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. 1970 Feb 20;167(3921):1136-7.
doi: 10.1126/science.167.3921.1136.

Pseudohermaphrodite rat: end organ insensitivity to testosterone

C W Bardin, L Bullock, G Schneider, J E Allison, A J Stanley

Pseudohermaphrodite rat: end organ insensitivity to testosterone

C W Bardin et al. Science. .

Abstract

The pseudohermaphrodite rat is characterized by lack of androgen-dependent differentiation. Treatment of these rats with testosterone failed to produce the expected changes in preputial and adrenal gland weights and hexobarbital metabolism. This insitivity of the end organ to testosterone could not be explained by defective formation of dihydrotestosterone.

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