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. 1970 Feb 27;167(3922):1266-8.
doi: 10.1126/science.167.3922.1266.

Oligodeoxyribonucleotides: chemical synthesis in anhydrous base

R Von Tigerstrom, M Smith

Oligodeoxyribonucleotides: chemical synthesis in anhydrous base

R Von Tigerstrom et al. Science. .

Abstract

The sugar hydroxyl of a methoxytrityldeoxyribonucleoside reacts with a methoxytrityldeoxyribonucleoside phosphorofluoridate in dimethylformamide and potassium tertiary butoxide to yield the protected dinucleoside monophosphate. The reaction is fast and specific, and is used in a stepwise synthesis to prepare trinucleoside diphosphate and tetranucleoside triphosphate.

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