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. 1970 Mar 1;131(3):559-70.
doi: 10.1084/jem.131.3.559.

Association of lactoferrin with specific granules in rabbit heterophil leukocytes

M Baggiolini, C De Duve, P L Masson, J F Heremans

Association of lactoferrin with specific granules in rabbit heterophil leukocytes

M Baggiolini et al. J Exp Med. .

Abstract

Lactoferrin has been identified in rabbit heterophil leukocytes on the basis of its immunological reactivity, electrophoretic mobility, acid-resistant iron-binding properties, and spectral characteristics. Leukocyte lactoferrin was found to be exclusively localized in the specific (secondary) granules, which have been resolved from other subcellular components by zonal differential centrifugation and by isopycnic equilibration.

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