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Clinical Trial
. 1970 Jan 17;1(5689):139-42.
doi: 10.1136/bmj.1.5689.139.

Effect of ergotamine and ergometrine on forearm venous compliance in man

O G Brooke, B F Robinson
Clinical Trial

Effect of ergotamine and ergometrine on forearm venous compliance in man

O G Brooke et al. Br Med J. .

Abstract

The effect of ergotamine and ergometrine on the venous compliance of the forearm has been studied in normal persons. Ergotamine tartrate (0.25 mg. intravenously) led to a fall in venous compliance amounting to 49% on average, while ergometrine maleate (0.25 mg. intravenously) caused a reduction of 41%; these changes were statistically significant. The potent veno-constrictor action of these ergot alkaloids appears to be a major component of the circulatory response to small doses and may be important in provoking the harmfull cardiovascular side-effects (such as angina and pulmonary oedema) that are sometimes observed in patients with pre-existing heart disease.

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