doi: 10.1042/bj1160177.
Inhibition by alpha-amanitin of ribonucleic acid polymerase solubilized from rat liver nuclei
- PMID: 5414093
- PMCID: PMC1185343
- DOI: 10.1042/bj1160177
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Inhibition by alpha-amanitin of ribonucleic acid polymerase solubilized from rat liver nuclei
Biochem J.
1970 Jan.
Abstract
1. alpha-Amanitin inhibits in vitro the RNA polymerase solubilized from isolated rat liver nuclei. 2. In contrast with previous observations with whole nuclei, the inhibition occurs approximately to the same extent in the presence and in the absence of ammonium sulphate. 3. Evidence is presented that the toxin acts by interacting with the enzyme itself and not with DNA or other components.
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