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. 1970 Jan;19(1):196-8.
doi: 10.1128/am.19.1.196-198.1970.

Growth of Venezuelan equine encephalomyelitis virus in human diploid cell strain WI-38

M Reitman, L Green

Growth of Venezuelan equine encephalomyelitis virus in human diploid cell strain WI-38

M Reitman et al. Appl Microbiol. 1970 Jan.

Abstract

We demonstrated that Venezuelan equine encephalomyelitis (VEE) virus replicated in and adapted rapidly to human diploid cell strain WI-38. Peak titers of approximately 10(9.8) mouse intracerebral 50% lethal doses were obtained at low passage levels in Eagles basal medium supplemented with calf serum. VEE virus replicated poorly in serum-free medium. Propagation of VEE virus was accompanied by the production of hemagglutinin and cytopathogenic effects.

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