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. 1970 Apr 3;168(3927):133-5.
doi: 10.1126/science.168.3927.133.

Mixed lymphocyte cultures produce effector cells: model in vitro for allograft rejection

P Häyry, V Defendi

Mixed lymphocyte cultures produce effector cells: model in vitro for allograft rejection

P Häyry et al. Science. .

Abstract

Mouse peripheral lymphocytes sensitized in vitro by culturing with allogeneic lymphocytes produced immunospecific destruction of target cells, as measured by release of chromium-51. Thus the sensitizing and effector phases of the cell-bound immune response can both be studied in an in vitro system.

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