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. 1970 Apr 24;168(3930):485-7.
doi: 10.1126/science.168.3930.485.

Colcemid sensitivity of fission yeast and the isolation of colcemid-resistant mutants

S Lederberg, G Stetten

Colcemid sensitivity of fission yeast and the isolation of colcemid-resistant mutants

S Lederberg et al. Science. .

Abstract

Cell division of the fission yeast, Schizosaccharomyces pombe, is reversibly inhibited by the antimitotic agent Colcemid (N-deacetyl-N-methylcolchicine) in nutrient medium. Cell growth continiues until all cells become nonseparating cell doublets in a V configuration. Mutants have been isolated capable of uninhibited growth in the presence of concentrations of Colcemid mycostatic for the parent strain.

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