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. 1970 Mar;101(3):881-4.
doi: 10.1128/jb.101.3.881-884.1970.

Conversion of histidine to hercynine by Neurospora crassa

V N Reinhold, Y Ishikawa, D B Melville

Conversion of histidine to hercynine by Neurospora crassa

V N Reinhold et al. J Bacteriol. 1970 Mar.

Abstract

Cell-free extracts of Neurospora crassa mycelium catalyze the methylation of l-histidine to form hercynine (histidine betaine). The partially methylated compounds, alpha-N-methyl-l-histidine and alpha-N,N-dimethyl-l-histidine, are also methylated by the same enzyme preparation to form hercynine. All three methylation reactions are stimulated by the addition of S-adenosylmethionine.

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