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. 1970 May 15;168(3933):854-6.
doi: 10.1126/science.168.3933.854.

Catecholamine biosynthesis in brains of rats treated with morphine

D H Clouet, M Ratner

Catecholamine biosynthesis in brains of rats treated with morphine

D H Clouet et al. Science. .

Abstract

In the brains of rats without tolerance to morphine, the accumulation of [(14)C]dopamine formed from [(14)C]tyrosine injected intracisternally is increased, reaching a maximum in the hypothalamus and striatum 1 hour after administration of morphine. In tolerant rats, the rate of incorporation of carbon-14 into dopamine and into norepinephrine in these areas is more than twice that in animals that have received only one injection of morphine.

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