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. 1970 Jul 24;169(3943):375-7.
doi: 10.1126/science.169.3943.375.

Hemoglobin interaction: modification of solid phase composition in the sickling phenomenon

J F Bertles, R Rabinowitz, J Döbler

Hemoglobin interaction: modification of solid phase composition in the sickling phenomenon

J F Bertles et al. Science. .

Abstract

Direct analyses of solid phase formed by deoxygenating solutions of sickle-cell hemoglobin (Hb S) in the presence of certain other hemoglobin species show that hemoglobins A and C can participate in the filamentous fine structure characteristic of the sickling phenomenon. In contrast, fetal hemoglobin (Hb F) is nearly completely excluded.

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