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Clinical Trial
. 1976 Jan 10;1(7950):51-4.
doi: 10.1016/s0140-6736(76)90148-3.

Oral disopyramide in prophylaxis of arrhythmias following myocardial infarction

G Jennings, M S Jones, E M Besterman, D G Model, P P Turner, P H Kidner
Clinical Trial

Oral disopyramide in prophylaxis of arrhythmias following myocardial infarction

G Jennings et al. Lancet. .

Abstract

Oral disopyramide given prophylactically following myocardial infarction has been compared with placebo in a double-blind trial using continuous-tape monoriting of the electocardiogram. It caused a significant reduction in the incidence of ventricular arrhythmias and of the various degrees of heart-block. There was a significant reduction of reinfarction during hospital stay in patients who had received disopyramide. Disopyramide appears to be a safe and effective oral therapy in the prevention of potentially serious arrhythmias following myocardial infarction.

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