Metabolic responses to status epilepticus in the rat, cat, and mouse

Abstract

Prolonged sustained seizure activity (status epilepticus) was created in rats and cats using paralysis and ventilation to prevent muscular contraction and its secondary systemic effects. Under physiologic control, seizure activity was maintained for 30, 60, and 120 min. At this time the brains were frozen using the in situ technique and the cortical tissue was analyzed for energy-related metabolites. The alteration of metabolites found at these times was similar to that previously described in the first 10 min of seizure activity. No evidence was found of any significant or progressive derangement of oxidative metabolism. A progressive lactic acidemia developed in spite of adequate arterial oxygen tensions. In contrast, when mice received a similar dose of the convulsant and were allowed to convulse freely in an oxygen-enriched environment, major derangements of energy metabolism were found which were progressive and persisted following recovery for at least 18 h.