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. 1979 Nov-Dec;13(6):1322-6.

[Binding of actinomycin D analogues containing some substituents at position 7 of the antibiotic chromophore to DNA]

[Article in Russian]
M V Mikhaĭlov, S M Nikitin, A C Zasedatelev, A L Zhuze, G V Gurskiĭ, B P Gottikh
  • PMID: 547179

[Binding of actinomycin D analogues containing some substituents at position 7 of the antibiotic chromophore to DNA]

[Article in Russian]
M V Mikhaĭlov et al. Mol Biol (Mosk). 1979 Nov-Dec.

Abstract

Spectrophotometric methods are used to study the binding to DNA of Actinomycin D (AMD) and its analogues: 7-nitro-AMD; 7-amino-AMD; 7-(Z-Val-Glo-NH)-AMD; 7-(AcO- . +H2-Val-Glo-NH)-AMD; 7-(AcO- . +H2-Val-Glo-Val-Glo-NH)-AMD. The binding constants are calculated from the binding isotherm of AMD and those of the AMD analogues to calf thymus DNA obtained by spectrophotometric titration. Introduction of smaller substituents such as the nitro or amino groups into position 7 of chromophore influences insignificantly the antibiotic binding to DNA, whereas bulky substituents cause a decrease in the affinity of the AMD analogues for DNA, although the spectral characteristics are not affected.

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