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. 1970 Oct 24;4(5729):210-2.
doi: 10.1136/bmj.4.5729.210.

Antilymphocyte serum and tissue culture used to investigate role of cell-mediated response in viral encephalitis in mice

G A Rook, H E Webb

Antilymphocyte serum and tissue culture used to investigate role of cell-mediated response in viral encephalitis in mice

G A Rook et al. Br Med J. .

Abstract

Antilymphocyte serum given to suppress selectively the cell response to Langat virus in Swiss albino mice prolonged the average survival times. In vitro, lymph-node cells from virus-immunized mice were strongly cytotoxic for syngenic non-neuronal brain cells infected with virus. The implications of these findings are discussed, with particular reference to the concept of autoimmunity.

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