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. 1970 Oct 31;4(5730):271-3.
doi: 10.1136/bmj.4.5730.271.

Outbreak of anticonvulsant intoxication in an Australian city

J H Tyrer, M J Eadie, J M Sutherland, W D Hooper

Outbreak of anticonvulsant intoxication in an Australian city

J H Tyrer et al. Br Med J. .

Abstract

An outbreak of anticonvulsant intoxication occurred in epileptic patients in Australia during 1968-9. All affected patients studied in Brisbane were taking one brand of phenytoin. In 87% of them the blood phenytoin levels were above the therapeutic range. Reduction of phenytoin dosage relieved the intoxication in all patients. The excipient in the responsible phenytoin capsules had been changed several months before the outbreak, and this change was probably related causally to the altered blood phenytoin concentrations.

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References

    1. J Forensic Sci. 1966 Oct;11(4):552-9 - PubMed
    1. Med J Aust. 1968 Sep 21;2(12):515 - PubMed
    1. Med J Aust. 1968 Sep 14;2(11):480-1 - PubMed

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