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. 1970 Aug;118(5):883-6.
doi: 10.1042/bj1180883.

Ultrastructural studies on mitochondrial swelling

W H Butler, J D Judah

Ultrastructural studies on mitochondrial swelling

W H Butler et al. Biochem J. 1970 Aug.

Abstract

Mitochondrial swelling induced by valinomycin, calcium chloride and P(i) was studied after potassium permanganate fixation in suspension. Valinomycin induces a rapid K(+) influx, increase of the matrix space and out-folding of the cristae, with good preservation of the matrix material. This swelling is reversible but the cristae do not completely re-form and have a blebbed appearance. On repeated swelling and contraction cycles there is a gradual loss of matrix material. Calcium chloride and P(i) produce a slow swelling of the matrix space. Shrinkage induced by ATP was partial and not associated with return to the original structure.

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