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. 1970 Sep;23(6):533-7.
doi: 10.1136/jcp.23.6.533.

An assessment of techniques suitable for the diagnosis of sickle-cell disease and haemoglobin C disease in cord blood samples

G I Yaswon, R G Huntsman, J S Metters

An assessment of techniques suitable for the diagnosis of sickle-cell disease and haemoglobin C disease in cord blood samples

G I Yaswon et al. J Clin Pathol. 1970 Sep.

Abstract

Agar gel, cellulose acetate, and starch gel electrophoresis are all capable of diagnosing sickle-cell anaemia, sickle-cell haemoglobin C disease, and haemoglobin C disease in cord blood samples. Of these three electrophoretic techniques, agar gel is the easiest to interpret.Paper electrophoresis can reliably and rapidly detect sickle haemoglobin and haemoglobin C in cord blood samples. Being incapable of differentiating foetal and normal adult haemoglobin, the value of paper electrophoresis is limited to an initial screening procedure.

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References

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