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. 1970 Dec 18;170(3964):1320-2.
doi: 10.1126/science.170.3964.1320.

Marihuana: studies on the disposition and metabolism of delta-9-tetrahydrocannabinol in man

L Lemberger, S D Silberstein, J Axelrod, I J Kopin

Marihuana: studies on the disposition and metabolism of delta-9-tetrahydrocannabinol in man

L Lemberger et al. Science. .

Abstract

Delta(9)-Tetrahydrocannabinol (the major active component of marihuana) administered intravenously to normal human volunteers persists in plasma for more than 3 days (t(1/2) = 56 hours). Its metabolites appear in plasma within 10 minutes after administration and persist along with the precursor compound. Delta(9)-Tetrahydrocannabinol is completely metabolized in man, and the radioactive metabolites are excreted in urine and feces for more than 8 days.

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