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. 1975 Dec 27;2(7948):1269-71.
doi: 10.1016/s0140-6736(75)90608-x.

Effect of intravenous prednisolone in asthmatics with diminished adrenergic responsiveness

R Ellul-Micallef, F F Fenech

Effect of intravenous prednisolone in asthmatics with diminished adrenergic responsiveness

R Ellul-Micallef et al. Lancet. .

Abstract

The beta effects of adrenergic stimulation are often diminished in asthmatics in whom the condition is active. Corticosteroids are thought to lower the threshold of beta-adrenergic receptors to the response of catecholamines. A single intravenous injection of 40 mg prednisolone appeared to restore responsiveness to inhaled isoprenaline in eight out of ten chronic asthmatics who were previously non-responsive to catecholamines.

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