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Clinical Trial
. 1970 Nov 28;4(5734):532-4.
doi: 10.1136/bmj.4.5734.532.

Interference of iron with the absorption of tetracyclines in man

P J Neuvonen, G Gothoni, R Hackman, K Björksten
Clinical Trial

Interference of iron with the absorption of tetracyclines in man

P J Neuvonen et al. Br Med J. .

Abstract

Ferrous sulphate administered together with tetracycline and three of its derivatives-oxytetracycline, methacycline, and doxycycline-was found seriously to impair the absorption of these antibiotics. Thus even small doses of iron taken simultaneously should be avoided during tetracycline treatment.

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References

    1. Gastroenterology. 1967 Oct;53(4):590-9 - PubMed
    1. Antimicrob Agents Chemother (Bethesda). 1966;6:134-41 - PubMed
    1. Antibiotic Med Clin Ther (New York). 1957 Oct;4(10):627-41 - PubMed
    1. Nature. 1956 Mar 3;177(4505):433-4 - PubMed

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