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. 1970 Aug;39(4):688-95.
doi: 10.1111/j.1476-5381.1970.tb09894.x.

Noradrenaline and tyramine action on isolated atrial muscle of endotoxin-treated guinea-pigs

B Bhagat, D Cavanagh, B N Merrild, M W Rana, P S Rao

Noradrenaline and tyramine action on isolated atrial muscle of endotoxin-treated guinea-pigs

B Bhagat et al. Br J Pharmacol. 1970 Aug.

Abstract

1. Isolated left-atrial strips of guinea-pigs were driven electrically at a constant rate and log-concentration curves were determined for the positive inotropic effect of noradrenaline and tyramine.2. The atrial tissue from endotoxin-treated animals had a reduced sensitivity to noradrenaline and tyramine.3. After endotoxin, the sensitizing effect of cocaine on the response to noradrenaline was normal but accumulation of (3)H-noradrenaline in nerve terminals was markedly reduced.4. Atrial tissue of endotoxin-treated guinea-pigs responded normally to stretch.

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