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. 1970 Dec;19(6):895-9.

The chemotactic activity for neutrophil and eosinophil leucocytes of the trimolecular complex of the fifth, sixth and seventh components of human complement (C567) prepared in free solution by the 'reactive lysis' procedure

P J Lachmann, A B Kay, R A Thompson

The chemotactic activity for neutrophil and eosinophil leucocytes of the trimolecular complex of the fifth, sixth and seventh components of human complement (C567) prepared in free solution by the 'reactive lysis' procedure

P J Lachmann et al. Immunology. 1970 Dec.

Abstract

C[unk]567, prepared by the interaction of purified C[unk]56 with purified C7 in solution, has been shown to be chemotactic for neutrophils and eosinophils. This activity was not significantly affected by the presence of C8 and C9, even in substantial excess. However, if the interaction of C[unk]56 with C7 took place in the presence of an excess of erythrocytes, these cells bound the C[unk]567 and were converted to EC567; and no chemotactic factor was found.

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References

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    1. Nature. 1969 Apr 19;222(5190):244-7 - PubMed
    1. Immunology. 1969 Feb;16(2):231-9 - PubMed
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