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. 1970 Dec;20(6):875-9.
doi: 10.1128/am.20.6.875-879.1970.

Microbial aromatization of steroids into equilin

S N Sehgal, C Vézina

Microbial aromatization of steroids into equilin

S N Sehgal et al. Appl Microbiol. 1970 Dec.

Abstract

This report describes the bioconversion of 19-hydroxy-androsta-4, 7-diene-3, 17-dione into equilin with Nocardia rubra. Through mutation and improvement of medium and of conditions, the bioconversion could be improved to yield 40% equilin for a substrate concentration of 1 g/liter. Aromatization of several other 19-hydroxy and 19-nor substrates of the androstene series is reported, and the influence of various substitutions of the substrate molecule on aromatization is discussed.

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References

    1. Biochim Biophys Acta. 1961 May 13;49:387-9 - PubMed

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