[Wilson's disease in the German Democratic Republic. I. Genetics and epidemiology]
[Article in
German]
- PMID: 549306
Item in Clipboard
[Wilson's disease in the German Democratic Republic. I. Genetics and epidemiology]
[Article in
German]
Z Gesamte Inn Med.
.
Abstract
The experiences of the central institution for Wilson's disease are reported. On the basis of 126 patients who come from 90 clans with 92 families the authors adopt a definite attitude to the problem of genetics, epidemiology and genetic family consultation. The unexceptional validity of the autosomal-recessive hereditary transmission may be confirmed. An incidence of 2.9/100,000 is assumed, from which a gene frequency of 0.53% and a frequency of heterozygotes of 1.05% can be estimated. The questions of the genetic background of polyphenia are discussed.
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