[Swelling and contraction of rat liver mitochondria under the effect of hexachlorocyclohexane gamma-isomer and polychlorocamphene]

Abstract

Swelling and contraction of the rat liver mitochondria were studied as affected by chloroorganic pesticides of hexachlorocyclohexane gamma-isomer (gamma-HCCH) and polychlorocamphene (PCC). Administration for two days of gamma-HCCH in a dose of 34 mg/kg and PCC in a dose of 48 mg/kg established to ccause swelling of the liver mitochindria in vivo, a decrease in their ability to swelling in KCl and KH2PO4 and to contraction with addition of ATP. When gamma-HCCH is administered daily for six months in a dose of 1.7 mg/kg the indices under study rise and in case of PCC analogous adninistration in a dose of 2.4 mg/kg-- the drop. The found differince in the effect of the mentioned preparations when they are introduced to the animal organism for a long time might be connected with singularities in their cumulative properties.