Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1970 Dec;47(3):593-603.
doi: 10.1083/jcb.47.3.593.

The chemical nature of keratohyalin granules of the epidermis

A G Matoltsy, M N Matoltsy

The chemical nature of keratohyalin granules of the epidermis

A G Matoltsy et al. J Cell Biol. 1970 Dec.

Abstract

Keratohyalin granules were isolated in the native form from the epidermis of newborn rats by the use of citric acid and a detergent. The isolated granules revealed a fine granular substructure in the electron microscope similar to that seen in situ. Analyses of amino acids by automated column-chromatography showed that proline and cystine are present in large proportions whereas histidine is present in a small amount. Accordingly, it was concluded that keratohyalin represents a sulfur-rich amorphous precursor of the horny cell content, rather than a sulfur-poor side product of the keratinization process, or a unique histidine-rich protein as proposed by in situ histochemical and radioautographic studies.

PubMed Disclaimer

References

    1. J Invest Dermatol. 1965 Dec;45(6):422-31 - PubMed
    1. Anat Rec. 1965 Aug;152(4):525-35 - PubMed
    1. J Invest Dermatol. 1966 Jan;46(1):127-9 - PubMed
    1. J Invest Dermatol. 1966 Dec;47(6):551-60 - PubMed
    1. Proc Natl Acad Sci U S A. 1966 Aug;56(2):594-601 - PubMed