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. 1970 Dec;24(4):746-54.
doi: 10.1038/bjc.1970.89.

A human tissue culture cell line from a transitional cell tumour of the urinary bladder: growth, chromosone pattern and ultrastructure

C C Rigby, L M Franks
Free PMC article

A human tissue culture cell line from a transitional cell tumour of the urinary bladder: growth, chromosone pattern and ultrastructure

C C Rigby et al. Br J Cancer. 1970 Dec.
Free PMC article

Abstract

Cell cultures were made from 18 human bladder tumours. Three cell lines were maintained for seven transfer generations, but all had a "fibroblastic" morphology and a normal diploid karyotype. A fourth line has been maintained for over 80 transfer generations. This was derived from a well differentiated papillary tumour of bladder. Morphologically the light and electron microscopic structure of the cells resembled that of bladder tumours. The cells formed tumour nodules, with a similar structure, when transplanted into hamster cheek pouches. There is a stem line chromosome number of 48. Karyotypes of 60% of the stem line cells had one extra chromosome in Group C and one in Group D.

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References

    1. Br Med J. 1967 Feb 4;1(5535):273-7 - PubMed
    1. Stain Technol. 1965 Nov;40(6):333-8 - PubMed
    1. J Urol. 1965 Feb;93:217-23 - PubMed
    1. Cancer Res. 1959 Jul;19(6, Part 1):643-53 - PubMed
    1. J Natl Cancer Inst. 1959 May;22(5):1003-17 - PubMed