Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1970 Dec;23(9):781-3.
doi: 10.1136/jcp.23.9.781.

A rapid whole blood solubility test to differentiate the sickle-cell trait from sickle-cell anaemia

R G Huntsman, G P Barclay, D M Canning, G I Yawson

A rapid whole blood solubility test to differentiate the sickle-cell trait from sickle-cell anaemia

R G Huntsman et al. J Clin Pathol. 1970 Dec.

Abstract

A simple and rapid screening test which differentiates sickle-cell trait and sickle-cell anaemia is described. The test utilizes 0.1 ml of whole blood and is based on the low solubility of reduced sickle haemoglobin. Results intermediate between the sickle-cell trait and sickle-cell anaemia are obtained in unusual cases of sickle-cell anaemia with high foetal haemoglobin. The need to supplement the results with haematological and electrophoretic techniques is discusses.

PubMed Disclaimer

References

    1. JAMA. 1967 Oct 30;202(5):419-21 - PubMed
    1. Br Med J. 1968 Jul 13;3(5610):86-91 - PubMed
    1. J Indiana State Med Assoc. 1968 Dec;61(12):1651-2 - PubMed
    1. Arch Biochem Biophys. 1953 Nov;47(1):148-59 - PubMed
    1. Clin Chem. 1958 Apr;4(2):145-9 - PubMed

LinkOut - more resources