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. 1970 Oct;56(4):438-61.
doi: 10.1085/jgp.56.4.438.

Cellular inhomogeneity in dog red cells as revealed by sodium flux

Y Lange, R V Lange, A K Solomon

Cellular inhomogeneity in dog red cells as revealed by sodium flux

Y Lange et al. J Gen Physiol. 1970 Oct.

Abstract

Unidirectional (24)Na fluxes across the dog red blood cell membrane were measured. The kinetics were incompatible with a single time constant but could be accounted for in terms of a two-series compartment cell model, with approximately 1% of cell Na in the outer compartment. Dog red blood cells are known to be inhomogeneous in their Na and K permeabilities. Theoretical analysis showed that such cellular inhomogeneity in the Na permeability coefficient might in principle account for the flux data. In order to evaluate the inhomogeneity effect, a technique based on the differential response of cells suspended in isosmolar high K buffers was devised to measure the variations in Na permeability in the cell population. A variation in the Na permeability coefficient of approximately 30% was found. This inhomogeneity is insufficient to account for the flux data.

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References

    1. Q J Exp Physiol Cogn Med Sci. 1958 Jul;43(3):299-309 - PubMed
    1. J Gen Physiol. 1961 Nov;45:355-69 - PubMed
    1. J Physiol. 1958 Sep 23;143(2):325-31 - PubMed
    1. J Gen Physiol. 1954 May 20;37(5):631-41 - PubMed
    1. J Gen Physiol. 1955 Jan 20;38(3):371-88 - PubMed