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. 1970 Dec 1;132(6):1259-66.
doi: 10.1084/jem.132.6.1259.

Histocompatibility type and immune responsiveness in random bred Hartley strain guinea pigs

W J Martin, L Ellman, I Green, B Benacerraf

Histocompatibility type and immune responsiveness in random bred Hartley strain guinea pigs

W J Martin et al. J Exp Med. .

Abstract

Outbred Hartley strain guinea pigs capable of responding immunologically to 2,4-dinitrophenylated poly-L-lysine were shown to display a histocompatibility specificity in common with inbred strain 2 guinea pigs. This histocompatibility specificity was not detected in guinea pigs unable to respond immunologically to DNP-PLL. The result suggests that the poly-L-lysine specific immune response gene is very closely linked or even identical with a gene determining a major histocompatibility antigen in guinea pigs.

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