Abstract

PIP: 2 preparations of a sequential oral contraceptive containing 11 tablets of .1 mg mestranol and 10 tablets of .1 mg mestranol and 2 mg chlormadinone were compared: 127 women took the pills with 7 placebos (Eunomin) for 848 cycles and 47 women took them without placebos (GC 527) for 267 cycles. 1 pregnancy occurred due to patient error. No differences were recorded in weight changes, bone symptoms, breakthrough bleeding, breast symptoms, or increased libido. Mucorrhea and constipation were more common with the placebos. The side effects of nausea, nervousness, headache, fatigue, and decreased libido were frequent with placebos. 19.8% discontinued Eunomin, while 23.4% stopped taking CG 527. 76.9% of the women on Eunomin and 65.2% of those on CG 527 did not have the side effects that they had experienced with previou s pills.