doi: 10.1038/281259a0.
Contact inhibition and malignancy
- PMID: 551275
- DOI: 10.1038/281259a0
Item in Clipboard
Contact inhibition and malignancy
Nature.
.
Abstract
The role of contact inhibition in influencing the behaviour of malignant cells is discussed in a review. Although tissue culture cannot simulate the immense complexity of the conditions in vivo, some of the distinctive features of malignant invasion can be conveniently observed with this technique. The evidence derived from this technique indicates that defective contact inhibition of movement of malignant cells does contribute to their invasiveness.
Similar articles
-
Contact inhibition in tissue culture.In Vitro. 1970 Sep-Oct;6(2):128-42. doi: 10.1007/BF02616114. In Vitro. 1970. PMID: 4943054 Review. No abstract available.
-
Overlapping of normal and malignant mouse cells in pure and mixed cultures.Exp Cell Res. 1974 Mar 15;84(1):95-104. doi: 10.1016/0014-4827(74)90384-x. Exp Cell Res. 1974. PMID: 4856340 No abstract available.
-
Contact inhibition of movements in transformed and nontransformed cells.Birth Defects Orig Artic Ser. 1978;14(2):177-94. Birth Defects Orig Artic Ser. 1978. PMID: 346078 Review. No abstract available.
-
Studies of specific properties of tumour cell membranes using stereoscan microscopy.Eur J Cancer (1965). 1968 Oct;4(5):459-62. doi: 10.1016/0014-2964(68)90001-7. Eur J Cancer (1965). 1968. PMID: 5760728 No abstract available.
-
Contact inhibition of what? An analytical review.J Cell Physiol. 1973 Feb;81(1):25-37. doi: 10.1002/jcp.1040810104. J Cell Physiol. 1973. PMID: 4568376 Review. No abstract available.
Cited by
-
Boolean model of anchorage dependence and contact inhibition points to coordinated inhibition but semi-independent induction of proliferation and migration.Comput Struct Biotechnol J. 2020 Aug 4;18:2145-2165. doi: 10.1016/j.csbj.2020.07.016. eCollection 2020. Comput Struct Biotechnol J. 2020. PMID: 32913583 Free PMC article.
-
How inhibitory cues can both constrain and promote cell migration.J Cell Biol. 2016 Jun 6;213(5):505-7. doi: 10.1083/jcb.201605074. J Cell Biol. 2016. PMID: 27269064 Free PMC article.
-
Forcing contact inhibition of locomotion.Trends Cell Biol. 2015 Jul;25(7):373-5. doi: 10.1016/j.tcb.2015.05.001. Epub 2015 May 13. Trends Cell Biol. 2015. PMID: 25981318 Free PMC article.
-
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.Genes Dev. 2007 Nov 1;21(21):2747-61. doi: 10.1101/gad.1602907. Genes Dev. 2007. PMID: 17974916 Free PMC article.
-
Free edges in epithelial cell sheets stimulate epidermal growth factor receptor signaling.Mol Biol Cell. 2010 Jul 1;21(13):2172-81. doi: 10.1091/mbc.e09-12-1026. Epub 2010 May 12. Mol Biol Cell. 2010. PMID: 20462956 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
