A comparative study of the effects of anti-tumour and immunosuppressive drugs on antibody-forming and erythropoietic cells
- PMID: 5529340
- PMCID: PMC1712817
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A comparative study of the effects of anti-tumour and immunosuppressive drugs on antibody-forming and erythropoietic cells
Clin Exp Immunol.
1970 Jun.
Abstract
Immunosuppressive and erythroid cell line depressing activities of various agents used in cancer chemotherapy were investigated simultaneously in the same mice and compared to X-Rays. Vincristine, vinblastine, mitomycin C and actinomycin D had greater effects on erythropoiesis than on antibody-forming cells. By contrast, the immunosuppressive effects of cyclophosphamide, demecolcine and methotrexate exceeded markedly their erythropoietic toxicity. The Vinca alkaloids stimulated the secondary immune response, whereas X-Rays, antilymphocytic serum and the methylhydrazine derivatives inhibited the anamnestic response to a greater extent than the primary immune response.
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