[Ultrastructural observations on choroid melanoma]

Abstract

Twelve melanoblastomas of the choroid of different histological types have been studied in the semi-thin sections and at transmission electron microscope. There have been also observed at scanning electron microscope. The ultrastructural findings show some differences in the main cellular types as observed at light microscope by Callender (spindle-shaped cells A and B and epithelioid). In the epithelioid and spindle-shaped B cells a higher number of ribosomes and of mitochondria and large, polymorphous, often multiple nucleoli with reticular structure are observed. There findings may be related to a greater metabolic activity and anaplastic tendency of these cells. Moreover in spindle B - and epithelioid - cell types atypical melanogenesis and nuclear bodies are particularly evident. Scanning electron microscope show well developed cytoplasmic extensions in spindle cells.